Title:
Study of Countermeasures to Prevent Di(2-etylehexyl) Phtalate Elution from Blood Tubing
Kan-no Y.
1 ;Kan-no Y.
1 ;Kan-no Y.
2 ;Kan-no Y.
1 ;Kan-no Y.
1 ;Kan-no Y.
1 ;Kan-no Y.
1 ;Kan-no Y.
1
1. Department of Blood Purification
; 2. NIKKISO Medical Co Ltd
E-mail address corresponding author:
tshibamoto.kidc@med.tmd.ac.jp
Background:
A relationship between mechanical load and the elution of Di(2-etylehexyl) phthalate (DEHP) was observed with a primary focus on the blood tubing.
Methods:
Tubing was filled test solution and the test solution was circulated at a flow rate of 100mL/minute for 240 minutes. Before and after circulation, DEHP levels were measured. method-2): 5% bovine albumin test solution in the tubing was circulated for 60 minutes using tubing with different internal diameters (118mL and 136mL). Before and after circulation DEHP levels were measured. Four types of tubing were examined in this experiment: A commercially available tubing using DEHP, a commercially available tubing with an alternated pump tubing with a different silicon material, an alternated circuit with TOTM on the pump tubing, and an all TOTM tubing system.
Results:
With the commercially available tubing, the DEHP levels after circulation showed a greater increase than that before circulation. result-2): There was no elution observed with TOTM tubing. The system with silicon material only on the pump tubing and the alternated TOTM tubing prevented DEHP elution fifty percent more than the commercial available tubing circuits.
Conclusion:
Fifty percent of DEHP elution in the entire tubing was derived from the pump tubing site; Thus, fifty percent of DEHP elution can be prevented by changing of the pump tubing material and its placement method. The DEHP and/or TOTM level was not detected in blood tubing with a TOTM plasticizer.
Subject:
Complications
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